Tumour markers are substances, usually proteinsthat are produced by the body in response to cancer growth or by the cancer tissue itself. Some tumour markers are specific for one type of cancer, while others are seen in several cancer types. Many of the well-known markers are seen in non-cancerous conditions as well as cancer.
A tumor marker is a substance that is made by the body because a cancer is present. Or it can be made by the cancer itself. Some of these markers are specific to one cancer.
However, marker concentrations were often only marginally raised, and are unlikely to provide sensitive guide to tumour burden. National Center for Biotechnology InformationU. Journal List Br J Cancer v.
Tumor markers are substances that are produced by the cancer or by other cells of the body in response to cancer. Tumor markers for breast cancer can be found in the blood and are checked using a blood test. Having a high level of a tumor marker suggests to the healthcare provider that cancer is present in the body, but by itself, a high tumor marker level is not enough to be sure that cancer is present.
At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains disputed. Changes in cancer antigen 15—3 CA and carcinoembryonic antigen CEA were prospectively monitored monthly and were also evaluated for the 3 months preceding secondary PD. CA increases in patients progressing on fulvestrant but may also increase in those experiencing clinical benefit; this should not be taken as a sign of PD without verification.
In breast cancer current guidelines do not recommend the routine use of serum tumour markers. As high sensitivity and specificity and different cut-off values have been reported for mucin-like carcinoma associated antigen MCAwe compared MCA with the above mentioned tumour markers and MCA-CA Distant metastases occurred 19 times in 18 6.
Doctor may use a variety of laboratory tests if cancer is suspected. In conducting lab tests for cancer, samples of blood, urine, other bodily fluids or tissue are examined for abnormal cells or tumor markers that may determine whether a person has the disease or a precancerous condition. Lab tests also may be used to screen high-risk patients, pinpoint the stage of cancer, identify treatment options and evaluate whether the cancer is responding to treatment.
Background: Although multiple serum-based tumor markers have been described for breast cancer, such as CABR Methods: The literature relevant to serum tumor markers in breast cancer was reviewed. Particular attention was given to systematic reviews, prospective randomized trials, and guidelines issued by expert panels.